Two independent ACC microarray data sets8, 10 were analyzed for genes whose expression is correlated with the common Wnt/β-catenin pathway target gene, AXIN2 (Supplementary Figure S1-A and Supplementary Table S1); combining results of the two cohorts, 21 mRNAs were positively correlated (adjust P-value<0.05 and Pearson's r>0.6 in both cohorts) and 1 mRNA was negatively correlated (adjust P-value<0.05 and Pearson's r<−0.6 in both cohorts) (Figure 1a). The gene discussed is AXIN2; the disease is adrenal cortex carcinoma.