Moreover, AFF3 expression is positively correlated with CCND1 expression (Supplementary Figure S6-B), which is a direct target of the Wnt/β-catenin pathway in breast cancer cells.38 These observations suggest that AFF3 expression is Wnt/β-catenin-dependent in breast cancers as it is in ACC. Here, AFF3 is linked to adrenal cortex carcinoma.