AFF3 and adrenal cortex carcinoma: AFF3 expression was significantly associated with a poor overall survival in the two cohorts of ACC, whether analyzed as a continuous variable (cohort 1: P=0.00927, hazard ratio=1.68, 95% confidence interval=1.12–2.51; cohort 2: P=0.00649, hazard ratio=2.2, 95% confidence interval=1.19–4.09) or after dichotomization between ACC with low and high AFF3 expression (Figure 4b).