BCL2 and cancer: They do so by indirectly interfering with the recruitment of SEC to chromatin from key cancer-related genes such as v-myc avian myelocytomatosis viral oncogene homolog (MYC), B-cell lymphoma 2 (BCL2) and cyclin-dependent kinase 6 (CDK6).41, 42, 43 It would therefore be worth pursuing the development of inhibitors that more directly interfere with the organization or stability of the SEC.