Several variants associated with cardiac disorders were detected, but only the LDB3 gene is directly associated with DCM (LIM domain-binding 3 gene LDB3; Cardiomyopathy, Dilated, 1C; OMIM#601493) and both sisters harbored the same missense variant (c.G352A, p.V118M; rs35507268). Here, LDB3 is linked to familial dilated cardiomyopathy.