The findings from this study revealed an inherent role of 5-HT1DR which binds Axin1 and dissociates β-catenin from the complex, moving β-catenin into the nucleus to activate the β-catenin/LEF1/TCF4/MMP-7 pathway in colorectal cancer metastasis (Figure 3C). The gene discussed is TCF4; the disease is colorectal cancer.