Indeed, intracellular α-synuclein aggregates are found in a variety of other neurodegenerative diseases, including multiple system atrophy and dementia with Lewy bodies, the so-called α-synucleinopathies, and are believed to form by a process involving the active translocation of soluble protein micro-aggregates along the microtubule network to converge on the microtubule organizing centre (MTOC/centrosome) [4,5,6,7]. This evidence concerns the gene SNCA and neurodegenerative disease.