PRAM1 and leukemia: On the other hand, PML-RARα regulated adapter molecule-1 (PRAM-1), an adaptor protein which is expressed and regulated during normal myelopoiesis is found to be down-regulated by PML-RARα fusion protein in NB4 cells, suggesting important contribution of this protein in signaling pathway involved in differentiation of leukemia promyelocytes [15].