APC and malignant colon neoplasm: Further investigations showed that NRIP1, which interacts with ERα [23], is the primary downstream gene of NOP14. The inhibitory effect of NRIP1 on carcinogenesis of colon cancer [17] and hepatocellular carcinoma [24] by up-regulating APC transcription and thus inhibiting the Wnt/β-catenin pathway, have been reported previously [17].