In summary, we have showed that NOP14 might be a potential early warning biomarker for breast cancer; moreover, low NOP14 level is intimately associated with more invasive and metastatic breast cancers, and NOP14 suppresses breast cancer by inhibiting the Wnt/β-catenin pathways, possibly by up-regulating NRIP1; and furthermore, survival analysis has suggested that NOP14 level is a potential prognostic marker for breast cancer patients. This evidence concerns the gene NRIP1 and breast cancer.