To answer this question, we explored the relationship between renal Nrf2 activation and Agt gene expression in the RPTs of wild type mice since we previously reported that high glucose stimulated Agt gene expression via ROS generation [79] and that transgenic mice overexpressing Agt in their RPTCs exhibited hypertension, albuminuria and renal injury [80]. The gene discussed is NFE2L2; the disease is Hypertension.