NFE2L2 and diabetes mellitus: Indeed, the recent study by Tan et al [81] demonstrated that low doses of dh404 lessened and high doses worsened diabetes-associated atherosclerosis and kidney disease in STZ-induced diabetic apoE−/− mice as well as the study by Vaziri et al. [82] demonstrated that in diabetic obese Zucker rats, low doses of dh404 restore Nrf2 activity and ameliorate kidney injury whereas high doses of dh404 reinforce proteinuria, renal dysfunction and histological abnormalities.