Indeed, the recent study by Tan et al [81] demonstrated that low doses of dh404 lessened and high doses worsened diabetes-associated atherosclerosis and kidney disease in STZ-induced diabetic apoE−/− mice as well as the study by Vaziri et al. [82] demonstrated that in diabetic obese Zucker rats, low doses of dh404 restore Nrf2 activity and ameliorate kidney injury whereas high doses of dh404 reinforce proteinuria, renal dysfunction and histological abnormalities. The gene discussed is NFE2L2; the disease is kidney disorder.