Our findings were consistent with those of previous studies on IL-18 polymorphisms and HCC risk [32–34], all of which observed a significant relationship between the −137G/C polymorphism and HCC risk, with a high G allele frequency being associated with an increased risk of HCC and, conversely, a low C allele frequency being associated with a decreased risk of HCC. The gene discussed is IL18; the disease is hepatocellular carcinoma.