In addition, in confirming the pro-angiogenic function of endothelial Jagged1 in tumors, we have identified a new role for it in promoting blood vessel maturation in tumor angiogenesis, since eJag1OE tumor vasculature presented increased coverage of SMA+ cells, whereas the vasculature of eJag1KO mutants presented the opposite phenotype. Here, SMN1 is linked to neoplasm.