These changes reflect the appearance of leukemic CD19+, CD20+, CD22+ B-cells with coexpression of CD5 and CD23 for CLL, CD11c, CD25 and CD103 for HCL, CD5 for MCL and CD10 for FL and are in good agreement with literature29, 30. This evidence concerns the gene CD22 and B-cell chronic lymphocytic leukemia.