The normalised densities of PBMC from the patients with B-cell malignancies CLL, HCL, SMZL, MCL, FL captured by the antibodies against the T-cell markers CD2, CD3, CD4, CD7, CD8 were significantly lower and by the antibodies against the B-cell markers CD19, CD20 and CD22 - significantly higher than for normal controls (see Fig. 6A–C for CLL, HCL and SMZL). The gene discussed is CD8A; the disease is B-cell chronic lymphocytic leukemia.