INS and digestive system neoplasm: The observed association between T1DM and cancer could be directly related to hyperglycemia or could be a marker of certain underlying biologic factors that alter cancer risk (eg, insulin resistance).1–3 Additionally, patients with T1DM are usually characterized by pancreas β-cell autoimmunity with insulin deficiency that normally requires lifelong provision of exogenous insulin, which is absorbed directly into systemic circulation.