PPP1R15A and Hypertension: The drug Guanabenz, which is an α2-adrenergic receptor agonist used to treat hypertension, was demonstrated to selectively inhibit the stress-induced eIF2α protein phosphatase regulatory subunit 15 A (PPP1R15A; a.k.a. GADD34, growth arrest and DNA damage-inducible protein 34) that forms a complex with PP1c [110], whereas Salubrinal also targets the constitutive PPP1R15B-PP1c complex.