YAP1 and helicoid peripapillary chorioretinal degeneration: Furthermore, heterozygous loss-of-function mutations in YAP1 in humans can result in autosomal dominant coloboma and a mutation within the Yap-binding domain of TEAD1 causes Sveinsson's chorioretinal atrophy (SCRA), an autosomal dominant loss of RPE, choroid, and photoreceptors radiating from the optic nerve head (Fossdal et al., 2004; Williamson et al., 2014).