PLEKHG5 and cancer: In order to elucidate whether Syx RhoGEF activity was important for VEGF-A/NRP1-induced DJM-1 cancer cell proliferation, we constructed a lentivirus vector encoding Syx WT or a Syx mutant with a point mutation at the position of 571 Leu replaced to Glu in order to lose binding and the activation of RhoA (Marx et al., 2005).