In renal cell carcinoma, the VEGF-A/NRP1 signal was found to activate Ras and promote tumor growth in vivo (Cao et al., 2012), while VEGF-A/NRP1 signals induced the phosphorylation of Akt leading to breast cancer cell survival (Bachelder et al., 2001). This evidence concerns the gene NRP1 and hereditary clear cell renal cell carcinoma.