Most probably limited by the sample size of current IHC study, the C1orf63 IHC score failed to correlate with OS of all the breast cancer patients, but is capable of predicting a better prognosis for breast cancer patients in TNM III ~ IV stages, strongly indicating that C1orf63 could also act as a tumor suppressor, especially in the advanced stage of breast cancer. The gene discussed is RSRP1; the disease is breast carcinoma.