ERBB2 and metastatic malignant neoplasm in the lymph nodes: For the 182 breast cancer patients, log rank test also demonstrated that, depth of invasion (P < 0.001), lymph node metastasis (P < 0.001), advanced TNM stage (P < 0.001) and negative PR (P = 0.036), positive HER-2 (P = 0.028) were poor prognostic factors for OS.