The possibility of a relationship to older age has previously been suggested on the basis of data combined from the detection of PIK3CA mutations in 5/84 (6.0%) CSCC and 10/100 (10.0%) cervical adenocarcinomas in patients from Sweden [38] suggesting age may be a global determinant for PIK3CA mutation susceptibility in cervical cancer. The gene discussed is PIK3CA; the disease is cervical adenocarcinoma.