Then a large-scale association analysis in individuals of European descent identified the following three variants associated with lipid levels and CAD risk: SNPs rs1169288, rs1495741 and rs10128711, which located in or near the hepatocyte nuclear factor 1-α (HNF1A) gene, N-acetyltransferase 2 (NAT2) gene and SPT2, Suppressor of Ty, domain containing 1 (SPTY2D1) gene, respectively [11]. Here, HNF1A is linked to coronary artery disorder.