Among the 6 SNPs, there were significant differences in the allele frequencies between CAD cases and controls for HNF1A rs1169288 (OR = 1.18, 95 % CI = 1.05–1.33, P = 0.006), MADD-FOLH1 rs7395662 (OR = 1.20, 95 % CI = 1.07–1.36, P = 0.002) and NAT2 rs1495741 (OR = 1.15, 95 % CI = 1.02–1.30, P = 0.024) (Table 4). The gene discussed is MADD; the disease is coronary artery disorder.