Among the 6 SNPs and the genetic risks scores (GRS), the minor alleles of HNF1A rs1169288 (odd ratio (OR) = 1.18, 95 % confidence interval (CI) 1.05–1.33, P = 0.006) and MADD-FOLH1 rs7395662 (OR = 1.20, 95 % CI 1.07–1.36, P = 0.002) as well as the GRS (P = 1.06 × 10-5) were significantly associated with increased risk of CAD after false discovery rate (FDR) correction. The gene discussed is FOLH1; the disease is coronary artery disorder.