On the basis of Garcia-Bilbao and collaborators work published in 2012, relatively higher discriminating power of non-tumoral vs. CRC fresh frozen biopsy samples could be achieved on the basis of a set of 7 transcripts (ENC1, ACAT1, TMEM132A, CMTM7, FAM60A, MADCAM1, DDX55) with RT-qPCR with 90.9 % sensitivity and 100 % specificity [32]. Here, MADCAM1 is linked to colorectal carcinoma.