Chitinase 3-like 1 (CHI3L1, alias HCgp39 or YKL-40) is a secreted glycoprotein that is not synthesized physiologically, but in inflammatory and cancerous states [46, 47], it proved to have an important role in macrophage recruitment and angiogenesis during colorectal cancer formation [48]. The gene discussed is CHI3L1; the disease is colorectal cancer.