CD4 and Cryptococcal meningitis: The objectives of this pooled multi-data analysis were to summarize the performance of the Alere Pima POC CD4 technology at three clinical thresholds [100 cells/μl (to identify patients in need of reflex testing for prevention of Cryptococcal meningitis); 350 cells/μl (to identify patients eligible for ART according to the 2010 WHO guidelines) and 500 cells/μl (to identify patients eligible for ART according to the 2013 WHO guidelines)] compared with several laboratory-based reference technologies and across global regions.