DBF4 and colorectal neoplasm: However, experimental and clinical studies examining the efficacy of Cdc7 kinase inhibitors in CRC are still needed as well as data on Dbf4 protein expression, since colorectal cancers have been shown to have strong levels of Dbf4 mRNA expression and Dbf4 expression levels were uniformly high among most colorectal tumors (Bonte et al.).