We demonstrated that concentrations of L- and D-lactate consistent with those observed in the uterine cervix inhibit class I and II HDACs, induce the hyperacetylation of H3 and H4 histones, increase chromatin accessibility and significantly enhance the DNA repair rate in cervical cancer cells, as evaluated by γ-H2AX and comet assays. Here, H2AX is linked to cervical carcinoma.