SHANK2 and cancer: Based on the multiplicity of LOH and/or GOH mutations displayed by these genes in the various cancer samples, they would represent potential cancer-related genes that merit further investigation: eight of these genes, viz. DLGAP1, SHANK2, EIF2B5, SAE1, INSR, ATXN1 and RBFOX1 are included in Fig. 4a along with 20 tumor-suppressor and cancer related genes from Table 2A-D.