Upon stimulation of the cells with either viral infection or intrinsic/extrinsic nucleic acids, MDA5 and RIG-I could interact with mitochondrial antiviral signaling protein (MAVS) [also known as IFN-beta promoter stimulator (IPS)-1], which activates signaling pathways of NFkappaB and interferon regulatory factors (IRFs) to trigger apoptosis of cancer cells [11, 12]. Here, RIGI is linked to cancer.