IFIH1 and melanoma: In addition to TLR3, there are other viral RNA sensors in the cells, including melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I), which have been implicated in mitochondrial apoptosis of human melanoma cells, as well as proimmunogenic apoptosis of human ovarian cancer cells [6, 7].