ARNT and cancer: Low oxygen tension modulates cancer cell metabolism through stabilization of hypoxia-inducible factor (HIF)-α subunits (HIF-1α, HIF-2α, and HIF-3α) that in turn translocate to the nucleus where they heterodimerize with the constitutive HIF1-β, also referred to as aryl hydrocarbon receptor nuclear translocator (ARNT), and the recruitment of cofactors [27].