In first instance Abel et al [26] suggested that BRAF mutated melanoma cell lines, when exposed to a BRAF inhibitor, undergo rapid increase of ErbB3 mRNA transcription/translation (1.5- to 3-fold) which makes cells more sensitive to stimulation by exogenously added ligand Neuregulin-1 (HRG or NRG1). This evidence concerns the gene HRG and melanoma.