APE1 was reduced in Aluminium induced neuro-inflammation in rat brains [27], but could induce the release of inflammatory cytokines like TNF-∝, IL-6 in macrophages [28] and was elevated in ulcerative colitis[29]; hence we need to determine a correlation, if any between altered APE1 and neuro-inflammation in rat brain/ spinal cords possibly due to higher astrocytes and immature OLformation (skewed cell differentiation) after single/ fractionated dose of IR. Here, APEX1 is linked to inflammatory response.