It is, however, well known that high levels of TC are associated with an increased pro-thrombotic state [24]; in addition studies on Apo-E knockout mice showed that hyperlipidaemia and atherosclerosis are associated with hearing impairment and histological findings of spiral modiolar artery stenosis and thickening of the vascular intima [25]. The gene discussed is APOE; the disease is Hearing impairment.