TOP1 and cancer: In multivariate analysis, OS was inversely associated with TOP1 expression (HR: 2.290; 95% CI: 1.055–4.971; p = 0.036); tumor stage (HR: 0.071; 95% CI: 0.030–0.167; p < 0.0001); and chemotherapy (HR: 0.330; 95% CI: 0.151–0.721; p = 0.005), and DFS was inversely associate with TOP1 expression (HR: 2.223; 95% CI: 1.150–4.299; p = 0.018), cancer stage (HR: 0.150; 95% CI: 0.072–0.310; p < 0.001), and recurrence (HR: 7.685; 95% CI: 4.294–13.753; p < 0.001; Table 1).