TOP1 and cancer: In addition, Disease Free Survival (DFS), the length of time after treatment during which no disease found, was also associated with TOP1 expression (HR: 1.939; 95% CI: 1.018–3.695; p = 0.044), cancer stage (HR: 5.669; 95% CI: 3.143–10.225; p < 0.0001), chemotherapy (HR: 1.774; 95% CI: 0.999–3.151; p = 0.050), and recurrence (HR: 7.775; 95% CI: 4.515–13.391; p < 0.0001).