TOP1 and neoplasm: In the univariate analysis, high TOP1 expression (HR: 2.465; 95% confidence interval (CI): 1.139–5.335; p = 0.022; Table 1), tumor stage (HR: 8.843; 95% CI: 4.200–18.619; p < 0.0001; Table 1) and tumor recurrence (HR: 0.453; 95% CI: 0.243–0.841; p = 0.012; Table 1) were all significantly correlated to OS.