Previous studies show that some common pathways are highly associated with various cancers, including CRC and lung cancer, such as focal adhesion [16, 17], pathways in cancer, regulation of actin cytoskeleton [18, 19], the MAPK signaling pathway [20–27], ECM-receptor interaction, the Wnt signaling pathway [28–32], and the p53 signaling pathway [33, 34]. The gene discussed is TP53; the disease is cancer.