At the same time, traditional clinical and pathological features of breast cancer, including nodal status, TNM stage, and internal molecular parameter, including Her-2 status, molecular subtype are also important prognostic indicators for breast cancer, multivariate Cox’s regression analysis demonstrated that nodal status, stage, HER2 status were independent prognostic factors for DFS and OS In addition to CA 15–3 and CEA. This evidence concerns the gene CEACAM5 and breast carcinoma.