As the BTB-ZF protein Ab is also highly oncogenic and expressed in the eye disc progenitor cells, we hypothesize that the JNK-induced expression of chinmo in scrib- + RasACT/NACT tumors could cooperate with Ab to maintain a progenitor-like cell state in the eye disc, and that this is required for scrib- + RasACT/NACT tumor overgrowth. This evidence concerns the gene SCRIB and neoplasm.