These included; 1) mesoderm and muscle-related gene sets (eg Contractile fibre/Myofibril/Myosin complex), consistent with cell migration and a mesenchymal-like phenotype; 2) Toll signaling/Inflammation (eg Regulation of Toll signaling pathway/Defense response/Immune response), consistent with an inflammation response and the attraction of hemocytes; and 3) Hormone signaling (eg Hormone activity), consistent with the failure of the tumor-bearing larvae to undergo an ecdysone-induced pupariation response (Fig 1D and S1 File). This evidence concerns the gene TLR4 and neoplasm.