Finally, JNK signaling within tumors induces the expression of cytokines capable of activating JAK/STAT signaling (Upd1/2/3), which is known to be required for scrib- + RasACT tumor overgrowth [25], and these genes were also induced by JNK within the tumors (S1 Table), further confirming the reliability of the expression array data. This evidence concerns the gene MAPK8 and neoplasm.