fru expression was upregulated by JNK, raising the possibility that fru, like chinmo, could have oncogenic activity; and br and ttk were repressed by JNK in the tumors, raising the possibility that they could normally represss tumorigenesis, in a similar way to which some mammalian BTB-ZF proteins are known to function as tumor suppressors. Here, ZBTB22 is linked to neoplasm.