These data are further validated in the Gal4-tk-Luc model in HeLa cells and in the 22Rv1 prostate cancer cells, where the degree of β-catenin co-activation of AR activity correlates with the level of FKBP52 expression (Figs 3B, 3C and 4). This evidence concerns the gene LGALS4 and Familial prostate cancer.