Tumor necrosis factor α-induced protein 8 (TNFAIP8), the first member of TNFAIP8 family, was originally identified by comparing two primary and two matched metastatic head and neck squamous cell carcinoma (HNSCC) cell lines using the methods of northern blot and differential display of mRNAs [1]. Here, TNFAIP8 is linked to head and neck squamous cell carcinoma.