Contrary to our initial hypothesis, the present study showed that persistent hyperglycemia evoked by exogenous glucose infusion evoked up-regulation of the Th2- (Gata3) and Treg (Foxp3) master genes in favor of Th1 (Tbx21) and Th17 (Rorc) in healthy condition, which was not found in the endotoxemic condition. Here, TBX21 is linked to Hyperglycemia.