Contrary to our initial hypothesis, the present study showed that persistent hyperglycemia evoked by exogenous glucose infusion evoked up-regulation of the Th2- (Gata3) and Treg (Foxp3) master genes in favor of Th1 (Tbx21) and Th17 (Rorc) in healthy condition, which was not found in the endotoxemic condition. This evidence concerns the gene FOXP3 and Hyperglycemia.