In particular, the mRNA expressions of IL-1β and IL-6 were augmented regardless of endotoxemia condition, and those of CD4+ T lymphocyte master genes, such as Gata3 and Foxp3, were increased under healthy condition without endotoxemia in the MLNs, following exposure to prolonged state of hyperglycemic insult for 24 hours. The gene discussed is IL1B; the disease is serum lipopolysaccharide activity.