DCC and cancer: Among the cancers that were positive for DCC expression, only 2/34 cancers (6 %) demonstrated both methylation and LOH, 13/34 (38 %) cancers LOH alone, and 8/34 cancers (24 %) methylation alone (cancers showing both DCC methylation and 18q LOH vs. the others, P = 0.0048, Pearson’s chi-square test; Fig. 2d).