DCC and gastric cancer: By stratifying gastric cancers based on individual defects in either UNC5C or DCC and their relationship with tumor stage, UNC5C alterations were found in 18 % (2/11 informative cases), 48 % (12/25 informative cases), 63 % (19/30 informative cases), and 64 % (7/11 informative cases) of stages I, II, III, and IV cancers, respectively, showing that UNC5C alterations gradually developed according to the progression of the TNM stage (Table 3).