When we categorized gastric cancers with LOH ratios higher than 0 as CIN-positive, 12/17 gastric cancers (71 %) with both DCC methylation and 18q LOH, 13/17 gastric cancers (76 %) with 18q LOH alone, 12/22 gastric cancers (55 %) with DCC methylation alone, and 6/25 cancers (24 %) negative for DCC alterations were categorized as CIN-positive (P = 0.0025, Pearson’s chi-square test). The gene discussed is DCC; the disease is cancer.