Of the samples that showed more than 1 % methylation in the UNC5C promoter, mean methylation levels of UNC5C were significantly higher in gastric cancers compared with their corresponding normal gastric mucosa specimens (17.4 % (95 % CI, 12.4–22.4 %] in gastric cancers; 6.3 % (95 % CI, 3.1–9.5 %] in normal gastric mucosa specimens; P < 0.0001, Wilcoxon/Kruskal–Wallis test; Fig. 3c–d). Here, UNC5C is linked to gastric cancer.