Cancers with UNC5C alterations were more frequently observed in advanced stages (37 % (14/38) for stages I and II vs. 63 % (26/41) for stages III and IV, P = 0.02, Pearson’s chi-square test) and in advanced categories for lymph node metastasis (25 % (5/20) for N0 vs. 59 % (35/59) for N1–N3, P = 0.008, Pearson’s chi-square test). The gene discussed is UNC5C; the disease is metastatic malignant neoplasm in the lymph nodes.