The LOH ratio calculated for the other seven loci was significantly highest in gastric cancers with both DCC methylation and 18q LOH (mean LOH ratio, 0.44; SD ±0.39) and in cancers with 18q LOH alone (mean LOH ratio, 0.44; SD ±0.34), intermediate in cancers with DCC methylation alone (mean LOH ratio, 0.16; SD ±0.18), and lowest in cancers negative for DCC alterations (mean LOH ratio, 0.05; SD ±0.10; P < 0.0001, Wilcoxon/Kruskal–Wallis test). The gene discussed is DCC; the disease is cancer.