Meanwhile, UNC5C alterations gradually increased according to the progression of the TNM stage and were found in 2/11 (18 %) of stage I, 12 of 25 (48 %) of stage II, 19 of 30 (63 %) of stage III, and 7 of 11 (64 %) of stage IV cancers (Table 3). The gene discussed is UNC5C; the disease is cancer.