When we categorized the cancers that showed LOH ratios higher than 0 as CIN-positive, 8/10 gastric cancers (80 %) with both UNC5C methylation and 4q LOH, 11/13 gastric cancers (85 %) with 4q LOH alone, 9/17 gastric cancers (53 %) with UNC5C methylation alone, and 11/39 cancers (30 %) negative for UNC5C alterations were categorized as CIN-positive (P = 0.001, Pearson’s chi-square test). Here, UNC5C is linked to cervical squamous intraepithelial neoplasia.