TP53 and neoplasm: Figure 3 shows the typical images of a tumor in the p53−/−small group. The central region is more oxidized. Figure 4 displays the typical images of a tumor in the p53−/−large group. The redox state distribution does not have any obvious oxidized central region but rather appears as a pattern of “hot” (more oxidized and higher Fp redox ratio) patches. Other tumors in the p53−/− group exhibited either the core–rim pattern as in Fig. 3 or the “hot” oxidized patches as in Fig. 4.