To test this hypothesis, we employed the Chance redox scanner to image the fluorescence of nicotinamide adenine dinucleotide (NADH) and flavoprotein (Fp) with 3D sub-millimeter resolution in two colon cancer lines xenografted in mice, one being p53 wt and the other p53−/−. Here, TP53 is linked to malignant colon neoplasm.