The criteria used to establish a diagnosis of BL have varied since its original description based on morphologic grounds in the endemic form, but it is now accepted that it is associated with translocation between the MYC oncogene and immunoglobulin gene [16], normally in the absence of chromosomal translocations involving oncogenes associated with diffuse large B cell lymphoma (DLBCL) [17, 18], and more recent studies have revealed further commonly associated mutations [19–21]. This evidence concerns the gene MYC and diffuse large B-cell lymphoma.