LTBR and carcinoma: Malignant transformation of hepatic adenoma to carcinoma is frequently accompanied by mutation of the β-catenin pathway.21 To investigate the ability of LTβR activation to drive AKT/CAT aggressiveness, we administered agonistic anti-LTβR mAb, clone 4H8 (anti-LTβR) for either 4 weeks or 8 weeks beginning at day 10 post transfection of C57/BL6 mice.