AKT1 and intrahepatic cholangiocarcinoma: The appearance of cholangiocellular lesions in AKT-transfected livers has been described.33 We expanded on this observation and demonstrate that LTβR agonism+AKT and to a greater extent LTβR agonism + AKT/CAT, results in tumour pathology characterised by lipogenic hepatic foci with interspersed regions of ICC.