AKT1 and familial pancreatic carcinoma: Additionally, evidence identifies TNF-mediated Notch signalling in the progression of pancreatic cancer.36 Canonical NF-κB signalling has been reported to be critical for AKT oncogenicity.37 Therefore, it is possible that LTβR-NF-κB regulation of AKT with subsequent activation of NICD could facilitate tumour formation.