LTβR-accelerated tumour burden was further documented by increased levels of the transfected oncogenes NICD, with increased levels of AKT, activated pAKTThr308, pAKTSer473, NICD and Hes1 observed at day 40 (figure 4E) by western blot with liver lysates derived from AKT/NICD/anti-LTβR treated mice. The gene discussed is AKT1; the disease is neoplasm.