CCND1 and intrahepatic cholangiocarcinoma: Using the AKT/NICD ICC model,15 we demonstrate additional LTβR-specific molecular changes occur in association with upregulation of c-MYC,38 cyclin D1, cyclin E139 and CAT.40, 41 It remains uncertain if these oncogenic proteins are directly regulated by LTβR signalling or indirectly induced by factors in the microenvironment.