Based on work from Sia et al,19 who molecularly defined ‘inflammatory’ and ‘proliferative’ subclasses of human ICC tumours with higher LTβR expression (2.3-fold) associating with ‘proliferative’ ICC subclass and worse survival, it is reasonable to conclude LTβ or LTβR expression could serve as a marker for proliferating ICC. The gene discussed is LTBR; the disease is intrahepatic cholangiocarcinoma.