ICC-like lesions form diffuse, ductular/pseudoglandular patterns with the appearance of mitotic figures (figure 3C arrows) with ICC-like nodules staining positive for CK8 (a marker of preneoplastic hepatic lesions15, 25), cholangiocyte marker CK19 (figure 3C), Ki-67, and Masson's trichrome (fibrosis) (see online supplementary figure S4). This evidence concerns the gene KRT19 and intrahepatic cholangiocarcinoma.