It remains unclear if LTβR mediated chemokine recruitment of inflammatory cells, and subsequent activation of NF-κB p65 and pSTAT3 observed in livers from AKT/CAT and AKT/NICD-transfected mice is promoting hepatocyte dedifferentiation or ICC-like formation. Here, NFKB1 is linked to intrahepatic cholangiocarcinoma.