Similar to AKT/CAT/anti-LTβR, AKT and AKT/anti-LTβR tumours were predominantly lipogenic hepatic foci, with LTβR agonism inducing the appearance of ICC-like nodules/regions by day 90 (figure 5B) and increasing frequency in moribund mice. This evidence concerns the gene AKT1 and intrahepatic cholangiocarcinoma.