Tumor suppressors miR-15a and miR-16 regulate tamoxifen sensitivity by targeting Bcl-2 [7], miR-451 targets 14-3-3ζ [39], let7s target ER-α36 [15], miR-375 targets metadherin [9] and miR-200b/c target ZEB1 [10]. The gene discussed is BCL2; the disease is neoplasm.