In support of a mechanistic role of EMT in tamoxifen resistance of breast cancer cells, over-expression of Pin-1 [21], AKT [22], Nicastrin and Notch4 [23], FoxM1 [24], brachyury [25] as well as modulation of several microRNAs [9, 10] has been reported. Here, AKT1 is linked to breast cancer.