Here, the downregulated and upregulated activities of NF-κB/MMPs in 5-8F-shFlot-2 and 6-10B-Flot-2 cells, respectively, demonstrated that the pro-metastatic role of Flot-2 in NPC might result from its ability to promote MMPs expression by activating NF-κB. Here, NFKB1 is linked to nasopharyngeal carcinoma.