PTGS2 and infectious otitis media: Treatment with 5-FU (10.1 ± 3.4 ng/mL; P = 0.0004), vitamin D (11.2 ± 3.4 ng/mL; P = 0.02 × 10−3) or combining both drugs (9.1 ± 2.7 ng/mL; P = 0.005 × 10−3) significantly reduced the levels of COX-2 in tissue homogenates compared with ‘AOM’ group.