One study shows that no significant difference in genotype distribution of TAP1 and TAP2 polymorphisms was observed in women with cervical intraepithelial neoplasm (CIN) and controls [56], and a similar study conducted in India succeeded to reproduce this observation [57], however, in another similar study, significant differences in allele distribution between women with high-grade cervical neoplasm (CIN II or III) and women without was seen for both TAP1 I333V (P = 0.02) and TAP1 D637G (P = 0.01) [58]. This evidence concerns the gene TAP1 and cervical intraepithelial neoplasia.