We validated the differential expression of the keyTGF-β pathway genes TGFB2, TGFBR1 and SMAD2 inBT-549 and HF cells after siRNA-mediated downregulation of EZH2 andMEG3 transcripts (Fig. 3d,e and Supplementary Fig. 4c). This evidence concerns the gene SMAD2 and hydrops fetalis.