Repressive chromatin-associated lncRNAs also includeseveral lncRNAs (PCA3, GAS6-AS1, CECR7 and BDNF-AS1)that have been implicated in cancer or other cellular functions, and among thisBDNF-AS1 lncRNA has been shown to regulate gene expression by recruitingPRC2 (refs 30, 52,53, 54). The gene discussed is BDNF; the disease is cancer.