However, a recent study investigating the process of epithelial to mesenchymal transition (EMT) in ovarian cancer cell lines found low HER3 expression in intermediate mesenchymal cells, cells which had a more aggressive phenotype due to resistance to anoikis (a form of programmed cell death) and increased spheroid-forming capability in vitro [78]; hypoxia has been shown to induce EMT in ovarian cancer cells [22]. Here, ERBB3 is linked to ovarian cancer.