In addition to the ribosome, the normal- and CML-specific NPM1-doublets were in fact associated with a total of 20, 25 and 2 functional annotations of the GeneSetDB (GO)18, 19, Reactome pathway database20, and MSigDB (KEGG)14, respectively (Fisher’s exact test, Bonferroni adjusted P < 0.05) (Supplementary Tables 5-7). Here, NPM1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.