In particular, when we focused on NPM1-doublets that were uniquely lost or invoked in CML, we found that NPM1 was exceedingly co-expressed with the mRNAs of BCR-ABL related pathways and ribosomal hub proteins (RPL10A, RPL31 and RPL36A). Here, RPL31 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.