Consistently, the present results suggest that the decrease in TβRIII mRNA and protein expression in human TSCC cancer cells might be possibly due to TGF-β1 overexpression, which are resistant to the negative growth effects of TGF-β1 due to the loss of TβRIII, thereby restoring TGF-β1 sensitivity. The gene discussed is TGFB1; the disease is cancer.