Based on these findings we suggest that this gene deletion may have an oncogenic function because TP53 degradation is triggered by E3 ubiquitin ligase activity in the absence of MLF1. Hence, we hypothesize that MLF1 could act as a recurrent tumour suppressor gene in iT‐ALL, however functional studies will be needed to elucidate its role in leukaemogenesis. The gene discussed is TP53; the disease is acute lymphoblastic leukemia.