NPM1 and acute myeloid leukemia: This gene was originally identified as a partner of NPM1 in the translocation t(3;5)(q25;q34), commonly found in acute myeloid leukaemia (AML) and myelodysplastic syndromes and has been shown to play a key role in the leukaemogenesis of these neoplasias (Bras et al, 2012).