This notion aligns with our own KMT2A‐r negative case that also did not reveal any of the expected ETP somatic mutations, such as SETD2 or EZH2. Nevertheless EP300, a known ‘driver’ for ETP‐ALL (Zhang et al, 2012), was carried as a suspected germline mutation in patient BR4. The gene discussed is EP300; the disease is acute lymphoblastic leukemia.