IFNB1 and viral infectious disease: These data indicate that although pigeon CARDs induced comparative IFN-β levels as duck CARDs, pigeon RIG-I has weaker IFN-inducing activity than both duck RIG-I and goose RIG-I with or without virus infection, which implies that the maintenance of autorepression state or RNA-sensing ability differ in waterfowl and pigeon RIG-I.