Although the neural phenotype in MADD zebrafish model is associated with aberrant activation of the PPARG-ERK pathway and mTORC1 signaling resulting from mitochondrial dysfunction and oxidative stress, the detailed pathomechanism how mutant ETF-QO plays some roles in neurogenesis or maintenance is still unclear [24]. This evidence concerns the gene ETFDH and multiple acyl-CoA dehydrogenase deficiency.