In accordance with our study, Catania et al. conducted the study that CDK5 expression in the astrocytomas of grades II–IV was consistently stronger than that in a single grade I pilocytic astrocytoma, which was the first study to examine CDK5/p35 expression in human astrocytic tumors of varying grades. The gene discussed is CDK5; the disease is astrocytoma (excluding glioblastoma).