AKT1 and glioblastoma: Additionally, evidence points that CDK5-mediated phosphorylation of PIKE-A (isoform A of phosphatidylinositol 3-kinase enhancer), which is a novel pro-oncogenic and antiapoptotic element that activates protein kinase B (AKT) pathway and stimulates cell growth, promotes cell migration and invasion in glioblastomas [15].